Job Description

Reference:

0607-26

We are looking for a Research Technician to support our research studies exploring how a ubiquitin ligase contributes to DNA replication stress and repair. The position is funded by an Academy of Medical Sciences grant awarded to Dr. Panagiotis Kotsantis, and is available for 24 months. 

This role involves supporting studies in DNA replication stress response signalling, including:

  • Generate and characterise engineered cell lines with inducible gene expression, gene depletion, and targeted genetic modifications, including domain deletions and site-directed mutations.
  • Investigate cellular responses to DNA damage and replication stress using a range of molecular and cell biology approaches, including immunofluorescence microscopy, immunoblotting, DNA fibre assays, and micronucleus analysis.
  • Examine protein localisation and chromatin-associated dynamics at sites of DNA replication and genome maintenance using advanced ...

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