Principal Scientist si-RNA Design

Position Overview

At Roche, the siRNA Design Principal Scientist will design and optimize therapeutic siRNA candidates across a range of disease targets, integrating computational and empirical approaches from target assessment through to lead optimization for clinical development.

Responsibilities

• Lead the drug design strategy for oligonucleotides with a focus on siRNAs, delivering proof of concept and full‑scale lead optimization.
• Guide projects holistically, ensuring early design decisions align with late‑stage clinical and manufacturing requirements.
• Invent new advanced chemical modification patterns and sequence selection strategies to optimize therapeutic properties of siRNAs.
• Collaborate with AI experts to develop, validate, and apply AI design solutions, providing ground‑truth biological data and domain expertise.
• Act as the RNAi subject‑matter expert in cross‑functional teams and disease‑area coll...