Principal Scientist si-RNA Design

Position Summary

The siRNA Design Principal Scientist will play a key role in designing and optimizing therapeutic siRNA against various disease targets from target assessment through lead optimization. Responsibilities include leading drug design strategy, collaborating with AI experts, and ensuring cross‑functional alignment across therapeutic development.

Responsibilities

• Lead the drug design strategy for oligonucleotides with a strong focus on siRNAs, leveraging computational and empirical approaches for both proof of concept on novel targets and full‑scale lead optimization for clinical development.
• Guide projects holistically and ensure early design decisions align with late‑stage clinical and manufacturing requirements.
• Develop and invent new advanced chemical modification patterns and sequence selection strategies to optimize the pharmacological properties of siRNAs.
• Work in close partnership with AI experts to deve...