PhD Position F/M Mechanistic and Deep-Learning Models for Liver-Heart Interaction in TIPS procedures

Contexte et atouts du poste

This project is part of the European Artemis project

Mission confiée

Topic

The prevalence of metabolic associated steatotic liver disease (MASLD) has increased significantly over the past years. As this condition progresses, inflammation and liver damage can occur, leading to liver cirrhosis – the scarring of the liver. A scarred liver increases the resistance blood needs to overcome to pass through the organ. As a consequence, blood pressure increases in the portal vein, one of the vessels bringing blood to the liver, leading to portal hypertension. The body adapts by generating collateral vessels deviating blood from the detoxifying liver, and by pumping more blood which eventually can damage the heart. The TIPS procedure aims at lowering this pressure by adding an artificial shunt that further deviates blood from the liver. However much remains to understand in the liver-he...