Computational Postdoc

About the job

Computational Postdoc Voest Lab (fully funded) — Spatial Decoding of Unconventional Antitumor Immunity in Colorectal Cancer

We are recruiting a computational postdoctoral fellow to spearhead a cutting-edge project building on our discovery that B2M-mutant, CD8-evasive colorectal cancers can show exceptional responses to immunotherapy. By integrating large-scale spatial transcriptomic and proteomic data from immunotherapy-treated MSI tumors, this project aims to uncover the principles of potent antitumor immunity beyond CD8 T cells. The postdoc will be a key driver of a central project within the Voest/van de Haar group at the Netherlands Cancer Institute.

Based on DRUP study data (Nature, 2019), we previously published about the clinical paradox that B2M-mutant colorectal cancers, which are invisible to CD8 T cells, show exceptional immunotherapy responses due to specific vulnerabilities to other immune cells (Nature, 202...