Job Description

As a Bioprocess Engineer at Palico Biotech, you will lead the genetic architecture of our OmniCell™ platform. Your primary objective is to engineer “off-the-shelf” mesenchymal stem cells (MSCs) that remain invisible to the host immune system. You will oversee the design and execution of multiplexed gene-editing strategies to silence MHC/HLA markers while ensuring the long-term genomic stability and therapeutic potency of the modified cells.

Key Responsibilities
  • Genetic Design: Lead the development of CRISPR-Cas12b and base-editing protocols for silencing HLA Class I and II molecules.
  • Validation: Conduct high-throughput flow cytometry and NGS (Next-Generation Sequencing) to verify edit efficiency and off-target profiles.
  • Functional Assays: Design in vitro T-cell provocation assays to validate the immune-evasive properties of engineered lines.
  • Team Leadership: Supervise a team of junior researchers and...

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